Garrett County has a well-developed transportation network, creating easy customer access.
- U.S. Interstate 68 runs through the northern portion of Garrett County and intersects with U.S. Interstate 79 to the west and U.S. Interstate 70 to the east, which provides easy access to Interstate 81
- U.S. Route 50, a major east-west route stretching from Ocean City, Maryland on the Atlantic Ocean to West Sacramento, California, bisects Garrett County
- U.S. Route 40, which crosses 12 states and runs parallel to or concurrently with U. S. Interstates 64, 68, 70, and 95, also bisects Garrett County
- U.S. Route 219, a spur of U.S. Route 19, runs north to south in New York, Pennsylvania, West Virgnia, Virginia, and Garrett County, Maryland
- Well-maintained state highways, including Maryland Routes 135 and 495
- Garrett County Airport in McHenry offers passenger, freight, and grounds support services for commercial and generation aviation.
- International and regional airports within a two-to-three-hour drive, as well as other local/community airports
- Greater Cumberland Regional Airport
- Morgantown Municipal Airport offers three round-trip flights to Dulles International Airport on United Express
- Hagerstown Regional Airport offers daily flights to Dulles International and Pittsburgh International Airports on Sun Air Express
- Pittsburgh International Airport
- Dulles International Airport
- Reagan National Airport
- Baltimore-Washington International Airport
- Port of Baltimore, a foreign trade port, boasts seven public terminals, including the state-of-the-art Intermodel Container Transfer Facility and the Cruise Maryland Terminal.
- Extensive miles of rail throughout the region from CSX
